I can not remember where but there was a study done a few years ago on all the registry optimisers that came to the conclusion that they really did not do a great of good, and that as you state in the wrong hands they can do a lot of harm. Personally I don't use one, because of this. I do however manually check my registry to see what is there, and if I've not go the programme to match then I just delete the item. I also think that if there had been a real need for a registry optimiser then Microsoft would have done one by now.
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Seti
Microsoft have released a registry cleaner and it has been out for a while now.
Check it out
Windows Live OneCare safety scanner: Free online tool for PC health and safety
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