If Windows 10 prompts you to Please Insert a Disk into Drive when using some card readers, then this may interest you.

The current Dell Windows 10 installation media may prompt you to "Insert a disk" during the operating system installation on select systems with Media Card readers.

This issue is caused by a flaw in the scripting logic that assumes that any media card reader that is assigned a drive letter (Enumerated), that drive should contain media.
The workaround for this is to click "Continue" when the message appears, to continue with the Windows 10 installation, till a fix is found by Dell.