Expect an increase in native 64-bit malware, especially rootkits (may tangentially tie into digital certs, above).

Do not expect to see much in the way of additional BIOS-flashing trojans (a/k/a Mebromi), although interest and research in this area by malware authors is likely to increase.

We will see increased use of social networks' realtime search results for social engineering and Black Hat SEO.

Poisoned search engine results will continue to be a popular way of distributing malware.

The use of software wrappers by file download sites seeking to monetize downloads will increase; those that are poorly-implemented or have unwise default settings likely to be classified as PUAs.

There will be reports of a vulnerability in the forthcoming Windows 8 that is called a "major security flaw" only to find out—a few days or perhaps a week or so later—that it cannot be conventionally exploited or remains firmly in the realm of the theoretical.

No actual malware for Windows Phone 7 will appear, although we will see some increased interest in security for the Windows Phone platform as it becomes more popular.
Full read at Eset Blogs.